Vitamin

Folate

Vitamin studied for dna synthesis, homocysteine metabolism, pregnancy neural support. How it works, the dose and timing studied, what it interacts with, and the research behind the grade.

Grade A evidence strong: trials and meta-analyses agree Also known as Vitamin B9, methylfolate, folic acid
All compounds
Best for DNA synthesis, Homocysteine metabolism, Pregnancy neural support
Typical dose 400 mcg DFE daily; 600 mcg in pregnancy
Timing Any time; with or without food
Category Vitamin
How it works

What it is and the mechanism

A B-vitamin essential for one-carbon metabolism, DNA and RNA synthesis, and conversion of homocysteine to methionine. Adequate intake before and during early pregnancy supports healthy neural tube development.

Dose and timing

When and how much to take

The dose below reflects the range used in published research. Match the form alongside the milligrams. Set your own wake and bed times to map the timing onto your day.

Timing visualizer

When to take Folate

Dose: 400 mcg DFE daily; 600 mcg in pregnancy. Set your own wake and bed times to map the guidance onto your day.

12a6a12p6pDAY1 dose
12 pmAnytime. Timing is flexible. Pick a slot you can keep consistent.

These statements have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure, or prevent any disease.

Before you stack it

Interactions and cautions

Read these before combining this with other supplements or medication. The risk is rarely the headline, it is the interaction you did not check.

Interactions
  • Methotrexate, antagonized by folate; coordinate with prescriber
  • Anticonvulsants, may lower folate
Cautions
  • High folic acid can mask B12 deficiency; pair with B12
  • Methylfolate suits those with MTHFR variants
Stacking

What pairs well, and what to keep apart

Derived from shared topics, complementary categories, and the interaction list. Introduce one compound at a time so you can tell what works.

Keep apart from

No direct compound conflicts derived. Still check the interactions list above against your medication.

Explore more

Compounds in the same topics

Often considered alongside this one. Each carries its own evidence grade.