Amino acid

L-Lysine

Amino acid studied for collagen formation, cold sore support, calcium absorption. How it works, the dose and timing studied, what it interacts with, and the research behind the grade.

Grade C evidence early: mostly mechanism or small studies
All compounds
Best for Collagen formation, Cold sore support, Calcium absorption
Typical dose 1–3 g daily
Timing On an empty stomach
Category Amino acid
How it works

What it is and the mechanism

An essential amino acid needed for collagen cross-linking, carnitine synthesis, and calcium absorption. It competes with arginine, the basis for its traditional use against herpes simplex outbreaks.

Dose and timing

When and how much to take

The dose below reflects the range used in published research. Match the form alongside the milligrams. Set your own wake and bed times to map the timing onto your day.

Timing visualizer

When to take L-Lysine

Dose: 1–3 g daily. Set your own wake and bed times to map the guidance onto your day.

12a6a12p6pDAY1 dose
12 pmAnytime. Timing is flexible. Pick a slot you can keep consistent.

These statements have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure, or prevent any disease.

Before you stack it

Interactions and cautions

Read these before combining this with other supplements or medication. The risk is rarely the headline, it is the interaction you did not check.

Interactions
  • Calcium, lysine increases its absorption
  • Aminoglycoside antibiotics, theoretical interaction
Cautions
  • High chronic doses are not well studied
  • GI upset possible at higher doses
Stacking

What pairs well, and what to keep apart

Derived from shared topics, complementary categories, and the interaction list. Introduce one compound at a time so you can tell what works.

Explore more

Compounds in the same topics

Often considered alongside this one. Each carries its own evidence grade.