Herb

Rhodiola rosea

Herb studied for mental fatigue, stress resilience, physical endurance. How it works, the dose and timing studied, what it interacts with, and the research behind the grade.

Grade B evidence moderate: promising but smaller or mixed human trials Also known as Arctic root, golden root
All compounds
Best for Mental fatigue, Stress resilience, Physical endurance
Typical dose 200–400 mg standardized extract (3% rosavins, 1% salidroside)
Timing Morning or early afternoon, on an empty stomach
Category Herb
How it works

What it is and the mechanism

Rosavins and salidroside are the primary bioactive compounds. They modulate monoamine neurotransmitters (serotonin, dopamine, norepinephrine) and HPA axis response, reducing stress-induced cortisol spikes without sedation.

Dose and timing

When and how much to take

The dose below reflects the range used in published research. Match the form alongside the milligrams. Set your own wake and bed times to map the timing onto your day.

Timing visualizer

When to take Rhodiola rosea

Dose: 200–400 mg standardized extract (3% rosavins, 1% salidroside). Set your own wake and bed times to map the guidance onto your day.

12a6a12p6pDAY1 dose
8 amMorning. Take early in the day.

These statements have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure, or prevent any disease.

Before you stack it

Interactions and cautions

Read these before combining this with other supplements or medication. The risk is rarely the headline, it is the interaction you did not check.

Interactions
  • MAOIs, theoretical serotonergic risk
  • Stimulants, additive CNS stimulation possible
Cautions
  • May have mild stimulant properties; avoid late in the day
  • Bipolar disorder, avoid without physician guidance
Stacking

What pairs well, and what to keep apart

Derived from shared topics, complementary categories, and the interaction list. Introduce one compound at a time so you can tell what works.

Keep apart from

No direct compound conflicts derived. Still check the interactions list above against your medication.

Explore more

Compounds in the same topics

Often considered alongside this one. Each carries its own evidence grade.