Other

Butyrate

Other studied for colon lining fuel, gut barrier support, metabolic health. How it works, the dose and timing studied, what it interacts with, and the research behind the grade.

Grade C evidence early: mostly mechanism or small studies Also known as Sodium butyrate, tributyrin
All compounds
Best for Colon lining fuel, Gut barrier support, Metabolic health
Typical dose 300–600 mg daily (as sodium or calcium-magnesium butyrate)
Timing With meals
Category Other
How it works

What it is and the mechanism

A short-chain fatty acid that is the preferred energy source for colonocytes. It supports the gut barrier, has anti-inflammatory effects, and acts as a histone deacetylase inhibitor influencing gene expression.

Dose and timing

When and how much to take

The dose below reflects the range used in published research. Match the form alongside the milligrams. Set your own wake and bed times to map the timing onto your day.

Timing visualizer

When to take Butyrate

Dose: 300–600 mg daily (as sodium or calcium-magnesium butyrate). Set your own wake and bed times to map the guidance onto your day.

12a6a12p6pDAY1 dose
1 pmWith a meal. Take alongside food to aid absorption and reduce stomach upset.

These statements have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure, or prevent any disease.

Before you stack it

Interactions and cautions

Read these before combining this with other supplements or medication. The risk is rarely the headline, it is the interaction you did not check.

Interactions
  • No well-characterized drug interactions
Cautions
  • Most butyrate is produced naturally by fermenting fiber
  • Human supplement evidence is early
Stacking

What pairs well, and what to keep apart

Derived from shared topics, complementary categories, and the interaction list. Introduce one compound at a time so you can tell what works.

Keep apart from

No direct compound conflicts derived. Still check the interactions list above against your medication.

Explore more

Compounds in the same topics

Often considered alongside this one. Each carries its own evidence grade.