Vitamin

Vitamin B12

Vitamin studied for energy metabolism, nerve function, red blood cell formation. How it works, the dose and timing studied, what it interacts with, and the research behind the grade.

Grade A evidence strong: trials and meta-analyses agree Also known as Cobalamin, methylcobalamin
All compounds
Best for Energy metabolism, Nerve function, Red blood cell formation
Typical dose 2.4 mcg daily (RDA); 500–1,000 mcg for correcting low levels
Timing Any time; sublingual or oral both work for most people
Category Vitamin
How it works

What it is and the mechanism

Water-soluble vitamin and cofactor for methionine synthase and methylmalonyl-CoA mutase, enzymes central to DNA synthesis, myelin maintenance, and energy metabolism. Deficiency causes fatigue, neurological symptoms, and megaloblastic anemia.

Dose and timing

When and how much to take

The dose below reflects the range used in published research. Match the form alongside the milligrams. Set your own wake and bed times to map the timing onto your day.

Timing visualizer

When to take Vitamin B12

Dose: 2.4 mcg daily (RDA); 500–1,000 mcg for correcting low levels. Set your own wake and bed times to map the guidance onto your day.

12a6a12p6pDAY1 dose
12 pmAnytime. Timing is flexible. Pick a slot you can keep consistent.

These statements have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure, or prevent any disease.

Before you stack it

Interactions and cautions

Read these before combining this with other supplements or medication. The risk is rarely the headline, it is the interaction you did not check.

Interactions
  • Metformin, reduces B12 absorption over time
  • Proton pump inhibitors, lower absorption of food-bound B12
Cautions
  • Vegans and older adults are at higher risk of low intake
  • Excess is excreted in urine; toxicity is rare
Stacking

What pairs well, and what to keep apart

Derived from shared topics, complementary categories, and the interaction list. Introduce one compound at a time so you can tell what works.

Keep apart from

No direct compound conflicts derived. Still check the interactions list above against your medication.

Explore more

Compounds in the same topics

Often considered alongside this one. Each carries its own evidence grade.