Mineral

Magnesium glycinate

Mineral studied for sleep quality, muscle relaxation, anxiety reduction. How it works, the dose and timing studied, what it interacts with, and the research behind the grade.

Grade B evidence moderate: promising but smaller or mixed human trials
All compounds
Best for Sleep quality, Muscle relaxation, Anxiety reduction
Typical dose 200–400 mg elemental magnesium
Timing 30–60 minutes before bed
Category Mineral
How it works

What it is and the mechanism

Magnesium acts as an NMDA receptor antagonist and activates GABA receptors, promoting neurological calm. Glycinate chelation improves intestinal absorption compared to oxide forms and avoids the laxative effect.

Dose and timing

When and how much to take

The dose below reflects the range used in published research. Match the form alongside the milligrams. Set your own wake and bed times to map the timing onto your day.

Timing visualizer

When to take Magnesium glycinate

Dose: 200–400 mg elemental magnesium. Set your own wake and bed times to map the guidance onto your day.

12a6a12p6pDAY1 dose
10 pmBefore bed. Take roughly 30 to 60 minutes before lights out.

These statements have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure, or prevent any disease.

Before you stack it

Interactions and cautions

Read these before combining this with other supplements or medication. The risk is rarely the headline, it is the interaction you did not check.

Interactions
  • Antibiotics (tetracyclines, quinolones, separate by 2 h)
  • Bisphosphonates
Cautions
  • Kidney disease, consult a physician before use
  • High doses may cause loose stools
Stacking

What pairs well, and what to keep apart

Derived from shared topics, complementary categories, and the interaction list. Introduce one compound at a time so you can tell what works.

Explore more

Compounds in the same topics

Often considered alongside this one. Each carries its own evidence grade.