Mineral

Magnesium L-threonate

Mineral studied for cognitive function, memory, brain aging. How it works, the dose and timing studied, what it interacts with, and the research behind the grade.

Grade B evidence moderate: promising but smaller or mixed human trials Also known as Magtein
All compounds
Best for Cognitive function, Memory, Brain aging
Typical dose 1.5–2 g (providing ~140 mg elemental magnesium)
Timing Split: morning and evening doses
Category Mineral
How it works

What it is and the mechanism

L-threonate is a metabolite of vitamin C that acts as a carrier, crossing the blood-brain barrier more efficiently than other magnesium forms, increasing synaptic density and NMDA receptor activity in the hippocampus.

Dose and timing

When and how much to take

The dose below reflects the range used in published research. Match the form alongside the milligrams. Set your own wake and bed times to map the timing onto your day.

Timing visualizer

When to take Magnesium L-threonate

Dose: 1.5–2 g (providing ~140 mg elemental magnesium). Set your own wake and bed times to map the guidance onto your day.

12a6a12p6pDAY2 doses
7 amMorning dose. Take the first portion after waking.
9 pmEvening dose. Take the second portion in the evening.

These statements have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure, or prevent any disease.

Before you stack it

Interactions and cautions

Read these before combining this with other supplements or medication. The risk is rarely the headline, it is the interaction you did not check.

Interactions
  • Other magnesium forms, combined elemental intake should not exceed ~500 mg/day
Cautions
  • More expensive than other forms; brain-specific benefits over standard glycinate are not definitively established in humans
Stacking

What pairs well, and what to keep apart

Derived from shared topics, complementary categories, and the interaction list. Introduce one compound at a time so you can tell what works.

Explore more

Compounds in the same topics

Often considered alongside this one. Each carries its own evidence grade.