Mineral

Manganese

Mineral studied for bone formation, antioxidant enzymes, connective tissue. How it works, the dose and timing studied, what it interacts with, and the research behind the grade.

Grade B evidence moderate: promising but smaller or mixed human trials
All compounds
Best for Bone formation, Antioxidant enzymes, Connective tissue
Typical dose 1.8–2.3 mg daily (adequate intake)
Timing Any time; with food
Category Mineral
How it works

What it is and the mechanism

A trace mineral cofactor for enzymes including manganese superoxide dismutase (mitochondrial antioxidant defense) and those involved in bone matrix and connective tissue formation.

Dose and timing

When and how much to take

The dose below reflects the range used in published research. Match the form alongside the milligrams. Set your own wake and bed times to map the timing onto your day.

Timing visualizer

When to take Manganese

Dose: 1.8–2.3 mg daily (adequate intake). Set your own wake and bed times to map the guidance onto your day.

12a6a12p6pDAY1 dose
1 pmWith a meal. Take alongside food to aid absorption and reduce stomach upset.

These statements have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure, or prevent any disease.

Before you stack it

Interactions and cautions

Read these before combining this with other supplements or medication. The risk is rarely the headline, it is the interaction you did not check.

Interactions
  • Iron, competes for absorption
  • Antacids and calcium, may reduce absorption
Cautions
  • Excess, especially inhaled, is neurotoxic; rarely needed as a standalone supplement
  • Stay within food-level intake
Stacking

What pairs well, and what to keep apart

Derived from shared topics, complementary categories, and the interaction list. Introduce one compound at a time so you can tell what works.

Explore more

Compounds in the same topics

Often considered alongside this one. Each carries its own evidence grade.