Amino acid

GABA

Amino acid studied for relaxation, stress reduction, sleep support. How it works, the dose and timing studied, what it interacts with, and the research behind the grade.

Grade C evidence early: mostly mechanism or small studies Also known as Gamma-aminobutyric acid
All compounds
Best for Relaxation, Stress reduction, Sleep support
Typical dose 100–300 mg
Timing 30–60 minutes before bed or during stress
Category Amino acid
How it works

What it is and the mechanism

The primary inhibitory neurotransmitter in the brain. Oral GABA crosses the blood-brain barrier poorly, so reported relaxation effects may stem from enteric nervous system signaling rather than direct central action.

Dose and timing

When and how much to take

The dose below reflects the range used in published research. Match the form alongside the milligrams. Set your own wake and bed times to map the timing onto your day.

Timing visualizer

When to take GABA

Dose: 100–300 mg. Set your own wake and bed times to map the guidance onto your day.

12a6a12p6pDAY1 dose
10 pmBefore bed. Take roughly 30 to 60 minutes before lights out.

These statements have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure, or prevent any disease.

Before you stack it

Interactions and cautions

Read these before combining this with other supplements or medication. The risk is rarely the headline, it is the interaction you did not check.

Interactions
  • Sedatives and blood pressure medications, possible additive effect
Cautions
  • Blood-brain barrier penetration is debated
  • Generally well tolerated; mild tingling or breathlessness at high doses
Stacking

What pairs well, and what to keep apart

Derived from shared topics, complementary categories, and the interaction list. Introduce one compound at a time so you can tell what works.

Keep apart from

No direct compound conflicts derived. Still check the interactions list above against your medication.

Explore more

Compounds in the same topics

Often considered alongside this one. Each carries its own evidence grade.