Other

Spermidine

Other studied for autophagy support, cellular renewal, healthy aging (investigational). How it works, the dose and timing studied, what it interacts with, and the research behind the grade.

Grade C evidence early: mostly mechanism or small studies
All compounds
Best for Autophagy support, Cellular renewal, Healthy aging (investigational)
Typical dose 1–6 mg daily (often from wheat germ extract)
Timing Any time; with food
Category Other
How it works

What it is and the mechanism

A polyamine found in wheat germ and aged foods that induces autophagy, the cellular recycling process. Observational data link higher dietary intake to longevity; interventional human data are early.

Dose and timing

When and how much to take

The dose below reflects the range used in published research. Match the form alongside the milligrams. Set your own wake and bed times to map the timing onto your day.

Timing visualizer

When to take Spermidine

Dose: 1–6 mg daily (often from wheat germ extract). Set your own wake and bed times to map the guidance onto your day.

12a6a12p6pDAY1 dose
1 pmWith a meal. Take alongside food to aid absorption and reduce stomach upset.

These statements have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure, or prevent any disease.

Before you stack it

Interactions and cautions

Read these before combining this with other supplements or medication. The risk is rarely the headline, it is the interaction you did not check.

Interactions
  • No well-characterized drug interactions
Cautions
  • Human trials are preliminary
  • Generally well tolerated as a food-derived compound
Stacking

What pairs well, and what to keep apart

Derived from shared topics, complementary categories, and the interaction list. Introduce one compound at a time so you can tell what works.

Keep apart from

No direct compound conflicts derived. Still check the interactions list above against your medication.

Explore more

Compounds in the same topics

Often considered alongside this one. Each carries its own evidence grade.